Respiratory uptake and elimination of ethylene glycol monoethyl ether after experimental human exposure.

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Respiratory uptake and elimination of ethylene glycol monoethyl ether after experimental human exposure.

Ten male volunteers were exposed to ethylene glycol monoethyl ether (EGEE) under various conditions of exposure concentration and physical workload. Steady state levels of retention, atmospheric clearance, and rate of uptake were reached immediately after the start of the exposure period for all experimental conditions. Retention was high (64% in resting condition) and increased as physical exe...

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Ethylene glycol monoethyl ether and ethylene glycol monoethyl ether acetate teratology studies.

An inhalation teratology study was conducted in rats at 10, 50 and 250 ppm ethylene glycol monoethyl ether (EGEE) and in rabbits at 10, 50 and 175 ppm EGEE. This study was designed to supplement a study conducted for NIOSH which showed teratogenic effects in rats at 200 ppm EGEE and in rabbits at about 160 ppm EE. In this study, EGEE was found not to cause teratogenic effects at concentrations ...

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Developmental effects after inhalation exposure of gravid rabbits and rats to ethylene glycol monoethyl ether.

The effects of ethylene glycol monoethyl ether (EGEE) were determined on development in utero. Pregnant New Zealand White rabbits were exposed to air or 160 or 617 ppm EGEE for 7 hr/day from 1 to 18 days of gestation (dg). Virgin Wistar rats were exposed to 150 or 649 ppm EGEE or air 5 days/week for the 3 weeks immediately preceding their breeding. Sperm-positive rats were subsequently exposed ...

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Pulmonary absorption and elimination of ethylene glycol monoethyl ether acetate in man.

Ten male volunteers were exposed to ethylene glycol monoethyl ether acetate (EGEE-Ac) under various conditions of exposure and physical workload. As exposure proceeded, retention, atmospheric clearance, and uptake rate declined slowly to reach steady state levels after three to four hours. Retention increased as a consequence of higher exposure concentrations and of physical workload performed ...

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ژورنال

عنوان ژورنال: Occupational and Environmental Medicine

سال: 1986

ISSN: 1351-0711

DOI: 10.1136/oem.43.8.544